Acromegaly per se does not increase the risk for coronary artery disease

Acromegaly per se does not increase the risk for coronary artery disease.

CONTEXT Information about the risk and course of coronary artery disease (CAD) in acromegaly is limited. OBJECTIVE To evaluate CAD risk in acromegalic patients at diagnosis and after successful treatment during follow-up. SUBJECTS AND METHODS Twenty-five consecutive patients (age 45.1+/-10.6 years, 15 women) were studied at the time of diagnosis, and 19 patients were re-evaluated after 4.6+...

Anthropometric Measures and the Risk of Coronary Artery Disease

Low risk of coronary artery disease in patients with acromegaly.

The aims of this study are to determine the prevalence of coronary atherosclerosis in acromegalic patients and to investigate the relationship between the coronary artery calcium score (CS) and acromegaly status and clinical parameters [Framingham risk score (FRS)]. Fifty-six acromegalic patients and paired non-acromegalic volunteers were stratified according to the FRS into low-, intermediate-...

Increase in visceral fat per se does not induce insulin resistance in the canine model

OBJECTIVES To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance. METHODS Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (S...

Cardioplegic arrest does not increase the risk of atrial fibrillation after coronary artery bypass surgery.

OBJECTIVE Atrial fibrillation (AF) is the most common arrhythmia after coronary artery bypass grafting (CABG). It is a considerable source of morbidity, prolongs hospital stay and increases costs of treatment. Atrial cannulation, cardiopulmonary bypass and cardioplegic arrest have been suggested to play a role in the development of AF after CABG. The aim of this case-control study was to evalua...